Shifting the paradigm for maintenance therapy in advanced non-small-cell lung cancer
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چکیده
منابع مشابه
Shifting the paradigm for maintenance therapy in advanced non-small-cell lung cancer.
The standard of care in metastatic non-small-cell lung cancer (NSCLC) is to treat patients with a platinum doublet for 4 to 6 cycles and to offer second-line therapy upon progression. Maintenance therapy in NSCLC is defined as a therapeutic agent which is administered after first-line chemotherapy is complete, but before the disease progresses. While maintenance therapy is not yet universally a...
متن کامل[Maintenance therapy for advanced non-small-cell lung cancer].
Maintenance therapy is a new treatment strategy for advanced non-small-cell lung cancer(NSCLC), and it consists of switch maintenance and continuation maintenance.Switch maintenance is the introduction of a different drug, not included as part of the induction therapy, immediately after completion of 4 cycles of first-line platinum-based chemotherapy.Continuation maintenance is a continuation o...
متن کاملMaintenance therapies in advanced non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC) has the second highest incidence of any newly diagnosed cancer and also has the highest mortality of any cancer type [1]. The majority of patients present with late-stage disease, by which time systemic therapy (chemotherapy) has become the primary treatment and platinum doublet chemotherapy is the first-line choice among patients with advanced disease (stage ...
متن کاملIs there a role for maintenance therapy in advanced non-small-cell lung cancer?
Switch maintenance treatment has been found to be an effective strategy in prolonging overall survival. The benefit in progression-free survival and overall survival, reported with pemetrexed in patients with nonsquamous histology and erlotinib in unselected patients as switch maintenance, and their favorable toxicity profile allow them to be used as maintenance treatment after induction ther...
متن کاملMaintenance therapy for advanced non-small cell lung cancer: current status, controversies, and emerging consensus.
Maintenance therapy refers to the use of an active therapeutic agent for extended duration following frontline induction therapy for patients with advanced stage non-small cell lung cancer (NSCLC). Multiple clinical trials reported within the last few months have shown a beneficial role for maintenance therapy especially in select patient groups characterized by histology and/or molecular profi...
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ژورنال
عنوان ژورنال: Lung Cancer: Targets and Therapy
سال: 2010
ISSN: 1179-2728
DOI: 10.2147/lctt.s5909